The role of innate cytokines in inflammatory response

被引：38

作者：

Liew, FY ^{[1
]}

机构：

[1] Univ Glasgow, Dept Bacteriol & Immunol, Glasgow G11 6NT, Lanark, Scotland

来源：

IMMUNOLOGY LETTERS | 2003年 / 85卷 / 02期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

cytokines; IL-15; IL-18; inflammation; rheumatoid arthritis;

D O I：

10.1016/S0165-2478(02)00238-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mediators produced by innate immune response cells such as macrophages can profoundly influence adaptive immunity. Recent studies have shown that IL-15 and IL-18 play an influential role in inflammatory response. Here I present recent data mainly from our own laboratories illustrating the importance of IL-15 and IL-18 in the induction and perpetuation of chronic inflammation during experimental and clinical rheumatoid synovitis. These Findings suggest that antagonists to these cytokines may have a potential therapeutic role against organ-specific autoimmune diseases. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：131 / 134

页数：4

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