Iodine status of New Zealand residents as assessed by urinary iodide excretion and thyroid hormones

被引:51
作者
Thomson, CD
Colls, AJ
Conaglen, JV
Macormack, M
Stiles, M
Mann, J
机构
[1] Univ Otago, Dept Human Nutr, Dunedin, New Zealand
[2] Waikato Hosp, Dept Med, Hamilton, New Zealand
关键词
thyroid hormones; New Zealand;
D O I
10.1079/BJN19970208
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The aims of this study were (1) to compare various measures of I status, and (2) to assess urinary I and thyroid hormone status of residents of two areas of New Zealand where, before the iodization of salt, goitre was endemic due to low soil I. A total of 189 subjects (102 males, eighty-seven females) were recruited from the Dunedin Blood Transfusion Centre, and 144 (sixty-seven males, seventy-seven females) from the Waikato Blood Transfusion Centre between November 1993 and June 1994. Blood was taken for thyroid hormone assays, and subjects collected a fasting overnight urine specimen, a double-voided fasting urine sample, and a complete 24 h specimen for iodide and creatinine analyses. Positive correlations (P < 0.0001) between daily iodide excretion and iodide concentrations in fasting and double-voided fasting urines, identical median values for iodide concentrations in the three samples, and similar numbers of subjects classified as at risk from I deficiency disorders according to the International Committee for the Control of Iodine Deficiency Disorders/World Health Organization categories (World Health Organization, 1994) confirmed indications from earlier studies that fasting urine samples were suitable for population studies. However 24 h urinary iodide excretion remains the recommended measure for individual I status. Waikato residents excreted more iodide in urine and all measures were significantly greater than for Otago residents. However median urinary iodide excretions for both areas (60 and 76 mu g/d for Otago and Waikato respectively) were considerably lower than those reported previously for New Zealand. Thyroid hormone concentrations were within normal ranges. Our findings suggest that I status of New Zealanders may no longer be considered adequate and may once again be approaching levels of intake associated with clinical I deficiency.
引用
收藏
页码:901 / 912
页数:12
相关论文
共 31 条
[1]  
[Anonymous], 1990, Q REV BIOL
[2]  
BASTOMSKY CH, 1979, HORM METAB RES, V11, P301
[3]   STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT [J].
BLAND, JM ;
ALTMAN, DG .
LANCET, 1986, 1 (8476) :307-310
[4]  
BOURDOUX PP, 1993, NATO ADV SCI INST SE, V241, P119
[5]  
Clugston G., 1994, MODERN NUTR HLTH DIS, V1, P252
[6]  
COOPER GJS, 1984, NEW ZEAL MED J, V97, P142
[7]  
*DEP HLTH, 1991, REP HLTH SOC SUBJ, V41, P183
[8]  
Dunn J. T., 1993, METHODS MEASURING IO
[9]  
FISHER KD, 1985, AM J CLIN NUTR, V42, P1318
[10]   IODINE INTAKE AND THE SEASONAL INCIDENCE OF THYROTOXICOSIS IN NEW-ZEALAND [J].
FORD, HC ;
JOHNSON, LA ;
FEEK, CM ;
NEWTON, JD .
CLINICAL ENDOCRINOLOGY, 1991, 34 (03) :179-181