A side effect resource to capture phenotypic effects of drugs

被引：655

作者：

Kuhn, Michael ^{[1
]}

Campillos, Monica ^{[1
]}

Letunic, Ivica ^{[1
]}

Jensen, Lars Juhl ^{[1
,2
]}

Bork, Peer ^{[1
,3
]}

机构：

[1] European Mol Biol Lab, Struct & Computat Biol Unit, D-69117 Heidelberg, Germany

[2] Univ Copenhagen, Fac Hlth Sci, Novo Nordisk Fdn Ctr Prot Res, Copenhagen, Denmark

[3] Max Delbruck Ctr Mol Med, Berlin, Germany

来源：

MOLECULAR SYSTEMS BIOLOGY | 2010年 / 6卷

关键词：

adverse drug reactions; database; drugs; human phenotypes; side effects; ERECTILE DYSFUNCTION; DATABASE; PREDICTION;

D O I：

10.1038/msb.2009.98

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The molecular understanding of phenotypes caused by drugs in humans is essential for elucidating mechanisms of action and for developing personalized medicines. Side effects of drugs (also known as adverse drug reactions) are an important source of human phenotypic information, but so far research on this topic has been hampered by insufficient accessibility of data. Consequently, we have developed a public, computer-readable side effect resource (SIDER) that connects 888 drugs to 1450 side effect terms. It contains information on frequency in patients for one-third of the drug-side effect pairs. For 199 drugs, the side effect frequency of placebo administration could also be extracted. We illustrate the potential of SIDER with a number of analyses. The resource is freely available for academic research at http://sideeffects.embl.de. Molecular Systems Biology 6: 343; published online 19 January 2010; doi:10.1038/msb.2009.98

引用

页数：6

共 16 条

[1] Drug repositioning: Identifying and developing new uses for existing drugs
Ashburn, TT
Thor, KB
[J]. NATURE REVIEWS DRUG DISCOVERY, 2004, 3 (08) : 673 - 683
[2] Nonspecific medication side effects and the nocebo phenomenon
Barsky, AJ
Saintfort, R
Rogers, MP
Borus, JF
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 287 (05): : 622 - 627
[3] Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure
Bender, Andreas
Scheiber, Josef
Glick, Meir
Davies, John W.
Azzaoui, Kamal
Hamon, Jacques
Urban, Laszlo
Whitebread, Steven
Jenkins, Jeremy L.
[J]. CHEMMEDCHEM, 2007, 2 (06) : 861 - 873
[4] Drug target identification using side-effect similarity
Campillos, Monica
Kuhn, Michael
Gavin, Anne-Claude
Jensen, Lars Juhl
Bork, Peer
[J]. SCIENCE, 2008, 321 (5886) : 263 - 266
[5] Analysis of system structure-function relationships
Fliri, Anton F.
Loging, William T.
Volkmann, Robert A.
[J]. CHEMMEDCHEM, 2007, 2 (12) : 1774 - 1782
[6] Krejsa CM, 2003, CURR OPIN DRUG DISC, V6, P470
[7] Large-scale prediction of drug-target relationships
Kuhn, Michael
Campillos, Monica
Gonzalez, Paula
Jensen, Lars Juhl
Bork, Peer
[J]. FEBS LETTERS, 2008, 582 (08) : 1283 - 1290
[8] Elucidating mechanisms of drug-induced toxicity
Liebler, DC
Guengerich, FP
[J]. NATURE REVIEWS DRUG DISCOVERY, 2005, 4 (05) : 410 - 420
[9] BindingDB: a web-accessible database of experimentally determined protein-ligand binding affinities
Liu, Tiqing
Lin, Yuhmei
Wen, Xin
Jorissen, Robert N.
Gilson, Michael K.
[J]. NUCLEIC ACIDS RESEARCH, 2007, 35 : D198 - D201
[10] Drug therapy: Erectile dysfunction.
Lue, TF
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2000, 342 (24) : 1802 - 1813

← 1 2 →