The formal total synthesis of (±)-strychnine via a cobalt-mediated [2+2+2]cycloaddition

被引：79

作者：

Eichberg, MJ ^{[1
]}

Dorta, RL

Lamottke, K

Vollhardt, KPC

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Lawrence Berkeley Lab, Div Chem Sci, Berkeley, CA 94720 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 16期

关键词：

D O I：

10.1021/ol006131m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A short, highly convergent total synthesis of racemic isostrychnine, and thus strychnine, has been completed. The route involves 14 steps in the longest linear sequence and is highlighted by a cobalt mediated [2 + 2 + 2]cycloaddition of an alkynylindole nucleus to acetylene.

引用

页码：2479 / 2481

页数：3

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