Reverse Transcribing the Code for Chromosome Stability

被引：11

作者：

Artandi, Steven E. ^{[1
]}

Cooper, Julia Promisel ^{[2
]}

机构：

[1] Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA

[2] London Res Inst, Canc Res UK, Telomere Biol Lab, London WC2A 3PX, England

来源：

MOLECULAR CELL | 2009年 / 36卷 / 05期

关键词：

TELOMERASE; TETRAHYMENA; SENESCENCE; SEQUENCE; YEAST; RNA;

D O I：

10.1016/j.molcel.2009.11.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The linearity of eukaryotic chromosomes presents challenges to cells, as the presence of DNA "ends" poses problems for the DNA replication machinery and the cell's damage response systems. This year's Nobel Prize in Physiology or Medicine recognized groundbreaking studies establishing the telomere field as a crucial area of biomedical research.

引用

页码：715 / 719

页数：5

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