Mechanisms of chromosomal rearrangements in solid tumors: The model of papillary thyroid carcinoma

被引：32

作者：

Gandhi, Manoj ^{[1
]}

Evdokimova, Viktoria ^{[1
]}

Nikiforov, Yuri E. ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Pathol & Lab Med, Pittsburgh, PA 15213 USA

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2010年 / 321卷 / 01期

关键词：

Thyroid cancer; RET/PTC; Nuclear architecture; DNA repair; DOUBLE-STRAND BREAKS; INDUCED GENOMIC INSTABILITY; RET/PTC REARRANGEMENTS; RET PROTOONCOGENE; HIGH PREVALENCE; IONIZING-RADIATION; EXTERNAL RADIATION; SPATIAL PROXIMITY; MAMMALIAN-CELLS; BRAF MUTATIONS;

D O I：

10.1016/j.mce.2009.09.013

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Thyroid cancer, and its most common type, papillary carcinoma, frequently have chromosomal rearrangements and therefore represent a good model for the understanding of mechanisms of chromosomal rearrangements in solid tumors. Several types of rearrangement known to occur in thyroid cancer, including RET/PTC, NTRK1 and BR4F/AKAP9, are more common in radiation-associated thyroid tumors and RET/PTC can be induced experimentally by exposing human thyroid cells to ionizing radiation. In this review, the molecular mechanisms of generation of RET/PTC and other chromosomal rearrangements are discussed, with the emphasis on the role of nuclear architecture and interphase gene proximity in the generation of intrachromosomal rearrangements in thyroid cells. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：36 / 43

页数：8

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