Effects of external magnetic field on biodistribution of nanoparticles: A histological study

被引：19

作者：

Wu, Tony

Hua, Mu-Yi

Chen, Jyh-ping

Wei, Kuo-Chen

Jung, Shih-Ming

Chang, Yeu-Jhy

Jou, Mei-Jie

Ma, Yunn-Hwa

机构：

[1] Chang Gung Univ, Coll Med, Dept Physiol & Pharmacol, Tao Yuan 333, Taiwan

[2] Chang Gung Univ, Coll Med & Mem Hosp, Dept Neurol, Taipei, Taiwan

[3] Chang Gung Univ, Dept Chem & Mat Engn, Tao Yuan, Taiwan

[4] Chang Gung Univ, Coll Med & Mem Hosp, Dept Neurosurg, Taipei, Taiwan

[5] Chang Gung Univ, Coll Med & Mem Hosp, Dept Pathol, Taipei, Taiwan

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2007年 / 311卷 / 01期

关键词：

nanoparticle; biodistribution; external magnetic field; Prussian blue stain; histology;

D O I：

10.1016/j.jmmm.2006.10.1202

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

This study investigates the effect of external magnetic fields on the biodistribution of nanoparticles (NP). A NdFeB magnet of 2.4 kG was externally applied over the left femoral artery or right kidney. The 250 nm dextran-coated Fe3O4 NP was injected via tail vein in healthy rats, and organs were taken 1 or 24 h later. Prussian blue stain revealed that NP were more rapidly retained in the liver and spleen than in the lungs. NP aggregation observed in the kidney and femoral artery after application of external magnets was time dependent. Hollow organs such as the intestine, colon, and urinary bladder retained little NP. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：372 / 375

页数：4

共 11 条

[1] Magnetic drug targeting: biodistribution and dependency on magnetic field strength [J].