Hypoglycemic and Hypolipidemic Effects of Hesperidin and Cyclodextrin-Clathrated Hesperetin in Goto-Kakizaki Rats with Type 2 Diabetes

被引：120

作者：

Akiyama, Satoko ^{[1
]}

Katsumata, Shin-ichi ^{[1
]}

Suzuki, Kazuharu ^{[1
]}

Nakaya, Yumi ^{[1
]}

Ishimi, Yoshiko ^{[2
]}

Uehara, Mariko ^{[1
]}

机构：

[1] Tokyo Univ Agr, Dept Nutr Sci, Fac Appl Biosci, Setagaya Ku, Tokyo 1568502, Japan

[2] Natl Inst Hlth & Nutr, Food Funct & Labeling Program, Shinjuku Ku, Tokyo 1628636, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2009年 / 73卷 / 12期

关键词：

hesperidin; Goto-Kakizaki rat; type; 2; diabetes; glucose-regulating enzyme; lipid; CITRUS FLAVONOIDS; LIPID-METABOLISM; GLUCOSE-UPTAKE; EXTRACT; LIVER; MICE; TRANSCRIPTION; ADIPONECTIN; NARINGENIN; EXPRESSION;

D O I：

10.1271/bbb.90576

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

We investigated the hypoglycemic and hypolipidemic effects of two hesperertin glycosides, namely, hesperidin and cyclodextrin (CD)-clathrated hesperetin, in Goto-Kakizaki (GK) weanling rats with type 2 diabetes. We demonstrated that hesperidin and CD-hesperetin normalized glucose metabolism by altering the activities of glucose-regulating enzymes and reducing the levels of lipids in the serum and liver of the GK rats. These effects of hesperidin glycosides were partly produced by altering the expression of genes encoding the peroxisome proliferator-activated receptors, 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, and the low-density lipoprotein receptor.

引用

页码：2779 / 2782

页数：4

共 23 条

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