Potential role of endothelin-1 and endothelin antagonists in cardiovascular diseases

被引：40

作者：

Schmitz-Spanke, S

Schipke, JD

机构：

[1] Univ Dusseldorf, Forsch Grp Expt Chirurg, Zentrum Operat Med 1, D-40225 Dusseldorf, Germany

[2] Univ Dusseldorf, Ctr Biomed Res, D-40225 Dusseldorf, Germany

来源：

BASIC RESEARCH IN CARDIOLOGY | 2000年 / 95卷 / 04期

关键词：

endothelin; cardiovascular system; receptor; pathophysiology; physiology;

D O I：

10.1007/s003950070048

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The endothelins comprise a family of three isopeptides ET-1, ET-2 and ET-3, whereby ET-1 appears to be the most relevant in humans. They act in a paracrine manner on ET, and ET, receptors. ET-1 plays an important role in the cardiovascular system. In addition, it modulates vasomotion and growth processes, and it participates in thrombogenesis and neutrophil adhesion. This review summarizes some of the current literature pertaining to the physiological and pathophysiological significance of ET-1, focusing the assets and drawbacks of elevated ET-1 levels. In this regard, modulation of the endothelin system by either receptor blockade or by inhibition of endothelin converting enzyme is expected to provide novel therapeutic drug strategies.

引用

收藏

页码：290 / 298

页数：9

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