Strategies for shotgun identification of post-translational modifications by mass spectrometry

被引：68

作者：

Cantin, GT ^{[1
]}

Yates, JR ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA

来源：

JOURNAL OF CHROMATOGRAPHY A | 2004年 / 1053卷 / 1-2期

关键词：

reviews; proteomics; proteins;

D O I：

10.1016/j.chroma.2004.06.046

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The global identification of post-translationally modified proteins is a difficult challenge that is currently being addressed by many researchers in the field of mass spectrometry (MS)-based proteomics. The ability to identify thousands of proteins by shotgun-based strategies has made the mere idea of a global analysis of a particular protein modification seem reasonable. There has been much progress in the development of methods that make use of shotgun-based protein identification in the analysis of a wide variety of protein modifications, some of which will be discussed here. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：7 / 14

页数：8

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