A decision aid for predicting non-sentinel node involvement in women with breast cancer and at least one positive sentinel node

被引：44

作者：

Farshid, G

Pradhan, M

Kollias, J

Gill, PG

机构：

[1] Inst Med & Vet Sci, Div Tissue Pathol, Adelaide, SA 5000, Australia

[2] Univ Adelaide, Hlth Informat Unit, Adelaide, SA, Australia

[3] Royal Adelaide Hosp, Adelaide, SA 5000, Australia

来源：

BREAST | 2004年 / 13卷 / 06期

关键词：

sentinel lymph node; breast cancer; histology; staging; decision making;

D O I：

10.1016/j.breast.2004.08.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Several clinical trials are re-evaluating the management of the axilla after sentinel node (SN) biopsy. Approximately 50-70% of patients with positive SN have no further nodal involvement. Estimates of the risk of non-sentinel node (NSN) involvement would aid decisions regarding further axillary surgery. Methods: Clinical and pathological variables for 82 breast cancer patients with metastasis to at least one SN, were used to find independent predictors of the status of NSNs. Results: NSN metastases were found in 46.3% of patients. In a regression model patient age, proportion of SN replaced by metastasis and number of SNs were independent predictors of NSN status. Conclusion: Data available after SN biopsy allow estimation of the risk of NSN metastases among patients with positive SNs. Individualised estimates of the risk of NSN involvement may facilitate discussions regarding the trade off between the likely benefits of further axillary surgery and the morbidity of this procedure. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：494 / 501

页数：8

共 26 条

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