Defective NK cell activity and Th1 response in IL-18-deficient mice

被引：782

作者：

Takeda, K

Tsutsui, H

Yoshimoto, T

Adachi, O

Yoshida, N

Kishimoto, T

Okamura, H

Nakanishi, K

Akira, S

机构：

[1] Hyogo Coll Med, Dept Biochem, Nishinomiya, Hyogo 663, Japan

[2] Hyogo Coll Med, Dept Immunol & Med Zool, Nishinomiya, Hyogo 663, Japan

[3] Hyogo Coll Med, Inst Adv Med Sci, Nishinomiya, Hyogo 663, Japan

[4] Osaka Maternal & Child Hlth Ctr, Res Inst, Osaka 59002, Japan

[5] Osaka Univ, Suita, Osaka 565, Japan

来源：

IMMUNITY | 1998年 / 8卷 / 03期

关键词：

D O I：

10.1016/S1074-7613(00)80543-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

IL-18 is a cytokine that is secreted from activated macrophages and induces IFN gamma production. To investigate the in vivo role of IL-18, we generated IL-18-deficient mice. In Propionibacterium acnes (P. acnes)-primed IL-18-deficient mice, LPS-induced IFN gamma production was markedly reduced, despite normal IL-12 induction. Natural killer cell activity was significantly impaired. Th1 cell response after injection of P. acnes or Mycobacterium bovis (bacillus Calmette-Guerin [BCG]) was significantly reduced. Similar results were observed in IL-12-deficient mice. Interestingly, Th1 response was induced after BCG infection in IL-12-deficient mice. We therefore generated mice lacking both IL-18 and IL-12. In these mice, NK activity and Th1 response were further impaired. This demonstrates the important role of both IL-18 and IL-12 in NK activity, as well as in in vivo Th1 response.

引用

页码：383 / 390

页数：8

共 36 条

[1]

Ahn HJ, 1997, J IMMUNOL, V159, P2125

[2] A newly defined interleukin-1? [J].

Bazan, JF ;

Timans, JC ;

Kastelein, RA .

NATURE, 1996, 379 (6566) :591-591

[3] MOLECULAR-CLONING OF THE INTERLEUKIN-1-BETA CONVERTING ENZYME [J].

CERRETTI, DP ;

KOZLOSKY, CJ ;

MOSLEY, B ;

NELSON, N ;

VANNESS, K ;

GREENSTREET, TA ;

MARCH, CJ ;

KRONHEIM, SR ;

DRUCK, T ;

CANNIZZARO, LA ;

HUEBNER, K ;

BLACK, RA .

SCIENCE, 1992, 256 (5053) :97-100

[4]

Conti B, 1997, J BIOL CHEM, V272, P2035

[5] Interferon-gamma-inducing factor, a novel cytokine, enhances Fas ligand-mediated cytotoxicity of murine T helper 1 cells [J].

Dao, T ;

Ohashi, K ;

Kayano, T ;

Kurimoto, M ;

Okamura, H .

CELLULAR IMMUNOLOGY, 1996, 173 (02) :230-235

[6] ADMINISTRATION OF RECOMBINANT IL-12 TO NORMAL MICE ENHANCES CYTOLYTIC LYMPHOCYTE ACTIVITY AND INDUCES PRODUCTION OF IFN-GAMMA IN-VIVO [J].

GATELY, MK ;

WARRIER, RR ;

HONASOGE, S ;

CARVAJAL, DM ;

FAHERTY, DA ;

CONNAUGHTON, SE ;

ANDERSON, TD ;

SARMIENTO, U ;

HUBBARD, BR ;

MURPHY, M .

INTERNATIONAL IMMUNOLOGY, 1994, 6 (01) :157-167

[7] Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production [J].

Ghayur, T ;

Banerjee, S ;

Hugunin, M ;

Butler, D ;

Herzog, L ;

Carter, A ;

Quintal, L ;

Sekut, L ;

Talanian, R ;

Paskind, M ;

Wong, W ;

Kamen, R ;

Tracey, D ;

Allen, H .

NATURE, 1997, 386 (6625) :619-623

[8] Activation of interferon-gamma inducing factor mediated by interleukin-1 beta converting enzyme [J].

Gu, Y ;

Kuida, K ;

Tsutsui, H ;

Ku, G ;

Hsiao, K ;

Fleming, MA ;

Hayashi, N ;

Higashino, K ;

Okamura, H ;

Nakanishi, K ;

Kurimoto, M ;

Tanimoto, T ;

Flavell, RA ;

Sato, V ;

Harding, MW ;

Livingston, DJ ;

Su, MSS .

SCIENCE, 1997, 275 (5297) :206-209

[9]

KAWAMURA I, 1992, J IMMUNOL, V148, P2887

[10]

Kohno K, 1997, J IMMUNOL, V158, P1541

← 1 2 3 4 →