A new Rac/PAK/GC/cGMP signaling pathway

被引：17

作者：

Guo, Dagang ^{[1
]}

Zhang, J. Jillian ^{[1
]}

Huang, Xin-Yun ^{[1
]}

机构：

[1] Cornell Univ, Dept Physiol, Weill Med Coll, New York, NY 10065 USA

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 2010年 / 334卷 / 1-2期

关键词：

Guanylyl cyclase; Rac; PAK; cGMP; DEPENDENT PROTEIN-KINASE; VASCULAR SMOOTH-MUSCLE; GUANYLYL CYCLASE-D; CELL-MIGRATION; P21-ACTIVATED KINASE; RHO-GTPASES; CYCLIC-GMP; ACTIVATION; GROWTH; ACTIN;

D O I：

10.1007/s11010-009-0327-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Guanosine 3',5'-cyclic monophosphate (cGMP) and small GTPase Rac are critical regulators of cell functions. Recently, Rac has been shown to use its downstream effector p21-activated kinase (PAK) to directly activate transmembrane guanylyl cyclases (GCs). This novel Rac/PAK/GC/cGMP signaling pathway bridges Rac and cGMP, and provides a general molecular mechanism for diverse receptors to regulate physiological functions such as cell migration through elevating the cellular cGMP level.

引用

页码：99 / 103

页数：5

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