Two mechanisms for termination of individual Ca2+ sparks in skeletal muscle

被引：35

作者：

Lacampagne, A ^{[1
]}

Klein, MG ^{[1
]}

Ward, CW ^{[1
]}

Schneider, MF ^{[1
]}

机构：

[1] Univ Maryland, Sch Med, Dept Biochem & Mol Biol, Baltimore, MD 21201 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2000年 / 97卷 / 14期

关键词：

D O I：

10.1073/pnas.97.14.7823

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Ca2+ sparks are brief, localized elevations of myoplasmic [Ca2+] caused by release of increments of Ca2+ via sarcoplasmic reticulum Ca2+ release channels in muscle. The properties of individual sparks provide information regarding the opening of sarcoplasmic reticulum Ca2+ channels within functioning cells. Here we use high-speed confocal microscopy to show that individual Ca2+ sparks activated by membrane depolarization in single frog skeletal muscle fibers can be terminated prematurely by repolarization. Thus, either voltage sensor deactivation on repolarization or release channel inactivation during continued depolarization can terminate the Ca2+ release channel activity underlying voltage-activated Ca2+ sparks in skeletal muscle.

引用

页码：7823 / 7828

页数：6

共 37 条

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