An endangered species in the stomach

被引:39
作者
Blaser, MJ [1 ]
机构
[1] NYU, Sch Med, Dept Med, New York, NY USA
[2] Vanderbilt Univ, Ctr Dis Control & Prevent, Nashville, TN 37240 USA
[3] Rockefeller Univ, Ctr Dis Control & Prevent, New York, NY 10021 USA
[4] Univ Colorado, Ctr Dis Control & Prevent, Boulder, CO 80309 USA
关键词
D O I
10.1038/scientificamerican0205-38
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Just as scientists were learning the importance of Helicobacter pylori they discovered that the bacteria are losing their foothold in the human digestive tract. Whereas nearly all adults in the developing world still carry the organism, its prevalence is much lower in developed countries such as the USA. Epidemiologists believe that H. pylori has been disappearing from developed nations for the past 100 years thanks to improved hygiene, which blocks the transmission of the bacteria, and to the widespread use of antibiotics. As H. pylori hasretreated, the rates of peptic ulcers and stomach cancer have dropped. But atthe same time, diseases of the esophagus, including acid reflux disease and aparticularly deadly type of esophageal cancer, have increased dramatically, and a wide body of evidence indicates that the rise of these illnesses is also related to the disappearance of H. pylori.
引用
收藏
页码:38 / +
页数:7
相关论文
共 3 条
[1]   Dynamics of Helicobacter pylori colonization in relation to the host response [J].
Blaser, MJ ;
Kirschner, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (15) :8359-8364
[2]  
BLASER MJ, 2004, J CLIN INVEST, V113, P231
[3]   Traces of human migrations in Helicobacter pylori populations [J].
Falush, D ;
Wirth, T ;
Linz, B ;
Pritchard, JK ;
Stephens, M ;
Kidd, M ;
Blaser, MJ ;
Graham, DY ;
Vacher, S ;
Perez-Perez, GI ;
Yamaoka, Y ;
Mégraud, F ;
Otto, K ;
Reichard, U ;
Katzowitsch, E ;
Wang, XY ;
Achtman, M ;
Suerbaum, S .
SCIENCE, 2003, 299 (5612) :1582-1585