Facile chromium carbene mediated synthesis of functionalised 5-to 7-ring lactones

被引：6

作者：

Good, GM

Kemp, MI

Kerr, WJ

机构：

[1] Univ Strathclyde, Dept Pure & Appl Chem, Glasgow G1 1XL, Lanark, Scotland

[2] Pfizer Ltd, Global Res & Dev, Sandwich Labs, Dept Discovery Chem, Sandwich CT13 9NJ, Kent, England

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 48期

关键词：

alkynes; chromium and compounds; lactones; sonochemistry;

D O I：

10.1016/S0040-4039(00)01684-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of pentacarbonyl[methoxy(2,6-dimethoxyphenyl)methylene]chromium(0) with acetylenic alcohols has been investigated. Reaction protocols have been optimised for rapid and direct access to functionalised gamma-, delta-, and epsilon -lactone products possessing enol ether (i.e. masked carbonyl) functionality. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：9323 / 9326

页数：4

共 7 条

[1] Functionalised β-lactones from chromium alkyl(alkoxy)carbene complexes [J].