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Regulatory binding partners and complexes of NHE3

被引：157
作者：
Donowitz, Mark
Li, Xuhang
机构：
[1] Johns Hopkins Univ, Sch Med, Dept Med, GI Div, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Sch Med, Dept Physiol, GI Div, Baltimore, MD 21205 USA
来源：
PHYSIOLOGICAL REVIEWS | 2007年 / 87卷 / 03期
关键词：
D O I：
10.1152/physrev.00030.2006
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Donowitz M, Li X. Regulatory Binding Partners and Complexes of NHE3. Physiol Rev 87: 825-872, 2007; doi:10.1152/physrev.00030.2006.-NHE3 is the brush-border (BB) Na+/H+ exchanger of small intestine, colon, and renal proximal tubule which is involved in large amounts of neutral Na+ absorption. NHE3 is a highly regulated transporter, being both stimulated and inhibited by signaling that mimics the postprandial state. It also undergoes downregulation in diarrheal diseases as well as changes in renal disorders. For this regulation, NHE3 exists in large, multiprotein complexes in which it associates with at least nine other proteins. This review deals with short-term regulation of NHE3 and the identity and function of its recognized interacting partners and the multiprotein complexes in which NHE3 functions.
引用
收藏
页码：825 / 872
页数：48
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