Postsynaptic signaling networks: Cellular cogwheels underlying long-term plasticity

被引:78
作者
Blitzer, RD
Iyengar, R
Landau, EM
机构
[1] Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA
[2] Mt Sinai Sch Med, Dept Pharmacol & Biol Chem, New York, NY 10029 USA
[3] Bronx Vet Affairs Med Ctr, Psychiat Serv, Bronx, NY USA
关键词
dendrites; hippocampus; long-term potentiation; LTP; protein synthesis; RNA granules; tagging;
D O I
10.1016/j.biopsych.2004.02.031
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Learning depends on positive or negative changes in synaptic transmission that are synapse-specific and sustained. Synaptic signals can be directly measured and respond to certain kinds of stimulation by becoming persistently enhanced (long-term potentiation, LTP) or decreased (long-term depression, LTD). Studying LTP and LTD opens a window on to the molecular mechanisms of memory. Although changes in both pre- and postsynaptic strength have been implicatcd in LTP and LTD, most attention has been focused on changes in postsynaptic glutamate receptor density. This is controlled by intracellular Ca2+ ions via a network of signaling molecules. Changes in postsynaptic Ca2+ concentration depend on the coincidence of appropriate synaptic signals, as is found in learning situations. The long-term persistence of LTP and LTD requires gene transcription and translation. It is posited that local translation at the synapse, in a self-sustaining manner, mediates the persistence of long-term change despite constant turnover of the synaptic components.
引用
收藏
页码:113 / 119
页数:7
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