Levels of total tau and tau protein phosphorylated at threonine 181 in patients with incipient and manifest Alzheimer's disease

被引：45

作者：

Schönknecht, P

Pantel, J

Hunt, A

Volkmann, M

Buerger, K

Hampel, H

Schröder, J

机构：

[1] Univ Heidelberg, Dept Psychiat, Sect Geriatr Psychiat, D-69115 Heidelberg, Germany

[2] Univ Heidelberg, Dept Internal Med, D-6900 Heidelberg, Germany

[3] Univ Munich, Dept Psychiat, Dementia Res Sect, D-8000 Munich, Germany

来源：

NEUROSCIENCE LETTERS | 2003年 / 339卷 / 02期

关键词：

tau protein; threonine; 181; Alzheimer's disease;

D O I：

10.1016/S0304-3940(02)01481-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cerebrospinal fluid tau protein levels are considered to be a promising marker for Alzheimer's disease (AD) and may facilitate early detection. Using the newly developed INNOTEST Phospho-Tau((181P)) kit examination of total tau and tau protein phosphorylated at threonine 181 (phospho-tau 18 1) revealed significantly (P < 0.05) higher values in both patients with incipient and manifest AD than in controls. In patients with vascular dementia, phospho-tau 181 levels were not different from controls but were significantly lower than in patients with manifest AD. These findings suggest that total and phosphorylated tau protein may facilitate early detection and differential diagnosis of AD. (C) 2003 Published by Elsevier Science Ireland Ltd.

引用

页码：172 / 174

页数：3

共 13 条

[1] Sensitivity, specificity, and stability of CSF-tau in AD in a community-based patient sample [J].

Andreasen, N ;

Minthon, L ;

Clarberg, A ;

Davidsson, P ;

Gottfries, J ;

Vanmechelen, E ;

Vanderstichele, H ;

Winblad, B ;

Blennow, K .

NEUROLOGY, 1999, 53 (07) :1488-1494

[2] CSF phosphorylated tau protein and mild cognitive impairment: a prospective study [J].

Arai, H ;

Ishiguro, K ;

Ohno, H ;

Moriyama, M ;

Itoh, N ;

Okamura, N ;

Matsui, T ;

Morikawa, Y ;

Horikawa, E ;

Kohno, H ;

Sasaki, H ;

Imahori, K .

EXPERIMENTAL NEUROLOGY, 2000, 166 (01) :201-203

[3] CSF total tau, aβ42 and phosphorylated tau protein as biomarkers for Alzheimer's disease [J].

Blennow, K ;

Vanmechelen, E ;

Hampel, H .

MOLECULAR NEUROBIOLOGY, 2001, 24 (1-3) :87-97

[4] Differential diagnosis of Alzheimer disease with cerebrospinal fluid levels of tau protein phosphorylated at threonine 231 [J].

Buerger, K ;

Zinkowski, R ;

Teipel, SJ ;

Tapiola, T ;

Arai, H ;

Blennow, K ;

Andreasen, N ;

Hofmann-Kiefer, K ;

DeBernardis, J ;

Kerkman, D ;

McCulloch, C ;

Kohnken, R ;

Padberg, F ;

Pirttilä, T ;

Schapiro, MB ;

Rapoport, SI ;

Möller, HJ ;

Davies, P ;

Hampel, H .

ARCHIVES OF NEUROLOGY, 2002, 59 (08) :1267-1272

[5] CSF tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects [J].

Buerger, K ;

Teipel, SJ ;

Zinkowski, R ;

Blennow, K ;

Arai, H ;

Engel, R ;

Hofmann-Kiefer, K ;

McCulloch, C ;

Ptok, U ;

Heun, R ;

Andreasen, N ;

DeBernardis, J ;

Kerkman, D ;

Moeller, HJ ;

Davies, P ;

Hampel, H .

NEUROLOGY, 2002, 59 (04) :627-629

[6] Tracking of Alzheimer's disease progression with cerebrospinal fluid tau protein phosphorylated at threonine 231 [J].

Hampel, H ;

Buerger, K ;

Kohnken, R ;

Teipel, SJ ;

Zinkowski, R ;

Moeller, HJ ;

Rapoport, SI ;

Davies, P .

ANNALS OF NEUROLOGY, 2001, 49 (04) :545-546

[7]

MCKHANN G, 1984, NEUROLOGY, V34, P939, DOI 10.1212/WNL.34.7.939

[8] CSF phosphorylated tau is a possible marker for discriminating Alzheimer's disease from dementia with Lewy bodies [J].

Parnetti, L ;

Lanari, A ;

Amici, S ;

Gallai, V ;

Vanmechelen, E ;

Hulstaert, F .

NEUROLOGICAL SCIENCES, 2001, 22 (01) :77-78

[9] VASCULAR DEMENTIA - DIAGNOSTIC-CRITERIA FOR RESEARCH STUDIES - REPORT OF THE NINDS-AIREN INTERNATIONAL WORKSHOP [J].

ROMAN, GC ;

TATEMICHI, TK ;

ERKINJUNTTI, T ;

CUMMINGS, JL ;

MASDEU, JC ;

GARCIA, JH ;

AMADUCCI, L ;

ORGOGOZO, JM ;

BRUN, A ;

HOFMAN, A ;

MOODY, DM ;

OBRIEN, MD ;

YAMAGUCHI, T ;

GRAFMAN, J ;

DRAYER, BP ;

BENNETT, DA ;

FISHER, M ;

OGATA, J ;

KOKMEN, E ;

BERMEJO, F ;

WOLF, PA ;

GORELICK, PB ;

BICK, KL ;

PAJEAU, AK ;

BELL, MA ;

DECARLI, C ;

CULEBRAS, A ;

KORCZYN, AD ;

BOGOUSSLAVSKY, J ;

HARTMANN, A ;

SCHEINBERG, P .

NEUROLOGY, 1993, 43 (02) :250-260

[10]

SCHONKNECHT P, 2003, IN PRESS PSYCHIAT RE

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