Acrylate as an efficient dimethylamine trap for the practical synthesis of 1-tert-butyl-4-piperidone via transamination

被引：10

作者：

Amato, JS

Chung, JYL

Cvetovich, RJ

Reamer, RA

Zhao, DL

Zhou, G

Gong, XY

机构：

[1] Merck Res Labs, Dept Proc Res, Rahway, NJ 07065 USA

[2] Merck Res Labs, Dept Analyt Res, Rahway, NJ 07065 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2004年 / 8卷 / 06期

关键词：

D O I：

10.1021/op049860g

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Efficient trapping of dimethylamine was the key to success in the transamination of 1,1-dimethyl-4-oxopiperidinium iodide with tent-butylamine to afford 1-tert-butylpiperidin-4-one in high yield. The use of sodium acrylate was found to provide an elegant way to both trap dimethylamine and provide a convenient method to allow purification in the subsequent extraction.

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页码：939 / 941

页数：3

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