Application of ionic liquids in liquid chromatography

被引：83

作者：

Marszall, Michal Piotr ^{[1
]}

Kaliszan, Roman ^{[1
]}

机构：

[1] Med Univ Gdansk, Dept Biopharmaceut & Pharmacodynam, PL-80416 Gdansk, Poland

来源：

CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY | 2007年 / 37卷 / 02期

关键词：

capillary electrophoresis; free silanols; ionic liquids; liquid chromatography; mobile phase additives;

D O I：

10.1080/10408340601107847

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Interest in ionic liquids (ILs) for their potential application in analytical chemistry continues to grow. Their usefulness can be due to favourable physicochemical properties, like the lack of vapour pressure, good thermal and chemical stability as well as very good dissolution properties regarding both organic and inorganic compounds. A specific feature of ILs is that these compounds provide strong proton donor-acceptor intermolecular interactions. As a result, ILs are able to affect on the hydroxy groups of the silica supports the most popular stationary phases in liquid chromatography (LC). It is well known that the hydroxy groups, called free or isolated silanols cause serious problems in LC, especially when separating basic compounds. This review focuses on the application of ILs in LC and capillary electrophoresis (CE) and comparisons of their efficiency with standard silanol suppressing additives to mobile phases.

引用

页码：127 / 140

页数：14

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