Functionalized platforms based on marine cyclopeptides: different pathways to the hexapeptide

被引：16

作者：

Boss, C ^{[1
]}

Rasmussen, PH ^{[1
]}

Wartini, AR ^{[1
]}

Waldvogel, SR ^{[1
]}

机构：

[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 33期

关键词：

coupling reagents; cyclisation; peptides; oxazoles; thiazoles;

D O I：

10.1016/S0040-4039(00)01057-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of macrocyclic, roughly planar, exclusively syn-functionalized hexapeptides, related to dolastatin I and bistratamide C from enantiomerically pure oxazole precursors is reported. The platforms can either be synthesized in a stepwise procedure by final cyclization of the linear oxazole trimers or in a direct 'one-pot' reaction. The investigation on the coupling of these building blocks into linear dimers and trimers with modern peptide coupling reagents is reported. (C) 2000 Published by Elsevier Science Ltd.

引用

页码：6327 / 6331

页数：5

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