Oryzias curvinotus has DMY, a gene that is required for male development in the medaka, O. latipes

被引：113

作者：

Matsuda, M

Sato, T

Toyazaki, Y

Nagahama, Y

Hamaguchi, S

Sakaizumi, M ^{[1
]}

机构：

[1] Niigata Univ, Grad Sch Sci & Technol, Niigata 9502181, Japan

[2] Natl Inst Basic Biol, Reprod Biol Lab, Okazaki, Aichi 4448585, Japan

来源：

ZOOLOGICAL SCIENCE | 2003年 / 20卷 / 02期

关键词：

medaka; DMY; DMRT1; sex determination;

D O I：

10.2108/zsj.20.159

中图分类号：

Q95 [动物学];

学科分类号：

071002 ;

摘要：

DMY is a Y-specific DM-domain gene required for male development and appears to be the sex-determining gene in the teleost fish medaka, Oryzias latipes. Although the genomic region containing DMY appears to have originated through duplication of the DMRT1 region, it is unknown when the duplication occurred. Here we show that O. curvinotus also has the DMY gene on the Y chromosome, which is homologous to the Y chromosome of medaka, and that DMY is expressed in XY embryos. A phylogenetic tree based on the amino acid sequence including the DIM-domain shows that DMY was derived from DMRT1 immediately before speciation of O. latipes and O. curvinotus.

引用

收藏

页码：159 / 161

页数：3

相关论文

共 16 条

[1] Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators [J].

Bowles, J ;

Schepers, G ;

Koopman, P .

DEVELOPMENTAL BIOLOGY, 2000, 227 (02) :239-255

[2] Genomic organization and expression of the doublesex-related gene cluster in vertebrates and detection of putative regulatory regions for DMRT1 [J].

Brunner, B ;

Hornung, U ;

Shan, Z ;

Nanda, I ;

Kondo, M ;

Zend-Ajusch, E ;

Haaf, T ;

Ropers, HH ;

Shima, A ;

Schmid, M ;

Kalscheuer, VM ;

Schartl, M .

GENOMICS, 2001, 77 (1-2) :8-17

[3] The expression pattern of a mouse doublsex-related gene is consistent with a role in gonadal differentiation [J].

De Grandi, A ;

Calvari, V ;

Bertini, V ;

Bulfone, A ;

Peverali, G ;

Camerino, G ;

Borsani, G ;

Guioli, S .

MECHANISMS OF DEVELOPMENT, 2000, 90 (02) :323-326

[4] Sexually dimorphic expression of two types of DM (Doublesex/Mab-3)-domain genes in a teleost fish, the Tilapia (Oreochromis niloticus) [J].

Guan, GJ ;

Kobayashi, T ;

Nagahama, Y .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 272 (03) :662-666

[5]

Kettlewell JR, 2000, GENESIS, V26, P174, DOI 10.1002/(SICI)1526-968X(200003)26:3<174::AID-GENE2>3.0.CO

[6]

2-J

[7] Differences in recombination frequencies during female and male meioses of the sex chromosomes of the medaka, Oryzias latipes [J].

Kondo, M ;

Nagao, E ;

Mitani, H ;

Shima, A .

GENETICAL RESEARCH, 2001, 78 (01) :23-30

[8] MEGA2: molecular evolutionary genetics analysis software [J].

Kumar, S ;

Tamura, K ;

Jakobsen, IB ;

Nei, M .

BIOINFORMATICS, 2001, 17 (12) :1244-1245

[9] DMRT1 expression during gonadal differentiation and spermatogenesis in the rainbow trout, Oncorhynchus mykiss [J].

Marchand, O ;

Govoroun, M ;

D'Cotta, H ;

McMeel, O ;

Lareyre, JJ ;

Bernot, A ;

Laudet, V ;

Guiguen, Y .

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 2000, 1493 (1-2) :180-187

[10] DMY is a Y-specific DM-domain gene required for male development in the medaka fish [J].

Matsuda, M ;

Nagahama, Y ;

Shinomiya, A ;

Sato, T ;

Matsuda, C ;

Kobayashi, T ;

Morrey, CE ;

Shibata, N ;

Asakawa, S ;

Shimizu, N ;

Hori, H ;

Hamaguchi, S ;

Sakaizumi, M .

NATURE, 2002, 417 (6888) :559-563