Id helix-loop-helix proteins in cell growth and differentiation

被引:426
作者
Norton, JD
Deed, RW
Craggs, G
Sablitzky, F
机构
[1] Christie Hosp NHS Trust, Paterson Inst Canc Res, Dept Gene Regulat, Canc Res Campaign, Manchester M20 9BX, Lancs, England
[2] UCL, Windeyer Inst Med Sci, Dept Med, London W1P 6DB, England
基金
英国惠康基金;
关键词
D O I
10.1016/S0962-8924(97)01183-5
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Id helix-loop-helix proteins function at a general level as positive regulators of cell growth and as negative regulators of cell differentiation. They act as dominant-negative antagonists of other helix-loop-helix transcription factors, which drive cell lineage commitment and differentiation in diverse cell types of higher eukaryotes. In addition, the functions of Id proteins are integrated with cell-cycle-regulatory pathways orchestrated by cyclin-dependent kinases and the retinoblastoma protein. Here, some of the recent advances that highlight the importance of Id proteins as regulatory intermediates for coordinating differentiation-linken gene expression with cell-cycle control in response to extracellular signalling are reviewed.
引用
收藏
页码:58 / 65
页数:8
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