The chemistry and pharmacology of tetrahydropyridines

被引：75

作者：

Mateeva, NN ^{[1
]}

Winfield, LL ^{[1
]}

Redda, KK ^{[1
]}

机构：

[1] Florida A&M Univ, Coll Pharm & Pharmaceut Sci, Tallahassee, FL 32307 USA

来源：

CURRENT MEDICINAL CHEMISTRY | 2005年 / 12卷 / 05期

关键词：

tetrahydropyridines; synthesis; pharmacology; structure-activity relationship;

D O I：

10.2174/0929867053362776

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tetrahydropyridine (THP) moiety is a part of many biologically active systems. The discovery of the neurotoxic properties of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) as well as numerous alkaloids, prompted extensive research on the synthesis and pharmacological properties of these compounds. The goal was extending the database for structure-activity relationship (SAR) studies. Consequently, many promising drug candidates were designed and a lot more are under clinical study. The current paper reviews the most popular approaches for the synthesis of THP derivatives. The pharmacological characteristics of some THP derivatives are summarized together with composite of the data from their in vitro, ex vivo and in vivo assays.

引用

页码：551 / 571

页数：21

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