PDGF-BB-induced DNA synthesis is delayed by angiotensin II in vascular smooth muscle cells

被引：8

作者：

Dahlfors, G ^{[1
]}

Chen, Y

Wasteson, M

Arnqvist, HJ

机构：

[1] Linkoping Univ, Fac Hlth Sci, Dept Cell Biol, S-58185 Linkoping, Sweden

[2] Linkoping Univ, Fac Hlth Sci, Dept Internal Med, S-58185 Linkoping, Sweden

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 1998年 / 274卷 / 05期

关键词：

rat; angiotensin AT(1) receptor; transforming growth factor-beta 1;

D O I：

10.1152/ajpheart.1998.274.5.H1742

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The interaction of ANG II with platelet-derived growth factor (PDGF)-BB-induced DNA synthesis was studied in cultured rat aortic smooth muscle cells. PDGF-BB-induced DNA synthesis was delayed (similar to 6-8 h) by ANG II as shown by a time-course experiment. Losartan, an AT(1)-receptor antagonist, blocked the transient inhibitory effect of ANG II, whereas the AT(2)-receptor antagonist PD-123319 had no effect. Autocrine- or paracrine-acting transforming growth factor-beta 1 (TGF-beta 1), believed to be a mediator of ANG II-induced inhibitory effects, was not responsible for the delay of PDGF-BB-induced DNA synthesis, because a potent TGF-beta 1 neutralizing antibody could not reverse this effect of ANG II, nor was the delay of the PDGF-BB effect caused by inhibition of PDGF-beta-receptor phosphorylation as shown by Western blot analysis of immunoprecipitated PDGF-beta receptor In conclusion, our results show that ANG II can exert a transient inhibitory effect on PDGF-BB-induced proliferation via the AT(1) receptor.

引用

页码：H1742 / H1748

页数：7

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