The control of bone remodeling by neuropeptide Y receptors

被引：34

作者：

Allison, S. J.

Baldock, P. A.

Herzog, H.

机构：

[1] St Vincents Hosp, Neurobiol Program, Garvan Inst Med Res, Sydney, NSW 2010, Australia

[2] St Vincents Hosp, Bone & Mineral Res Program, Garvan Inst Med Res, Sydney, NSW 2010, Australia

来源：

PEPTIDES | 2007年 / 28卷 / 02期

关键词：

bone remodeling; Y2; receptor; leptin; hypothalamus;

D O I：

10.1016/j.peptides.2006.05.029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An important role for the neuropeptide Y receptor system in the regulation of bone formation was recently revealed with a significant elevation in trabecular bone formation and bone volume following germline or hypothalamus-specific deletion of neuropeptide Y2 receptors in mice. Subsequent studies have now demonstrated that this central pathway is distinct from that of the other centrally regulated bone formation pathway mediated by leptin. This review discusses these recent findings and outlines how these new pathways could translate into potential novel targets for the treatment of bone disease. (c) 2006 Elsevier Inc. All rights reserved.

引用

收藏

页码：320 / 325

页数：6

相关论文

共 36 条

[1] EXTRACTION AND QUANTITATION OF NEUROPEPTIDES IN BONE BY RADIOIMMUNOASSAY [J].

AHMED, M ;

SRINIVASAN, GR ;

THEODORSSON, E ;

BJURHOLM, A ;

KREICBERGS, A .

REGULATORY PEPTIDES, 1994, 51 (03) :179-188

[2] NEUROPEPTIDE-Y, TYROSINE-HYDROXYLASE AND VASOACTIVE INTESTINAL POLYPEPTIDE-IMMUNOREACTIVE NERVE-FIBERS IN THE VERTEBRAL BODIES, DISKS, DURA-MATER, AND SPINAL LIGAMENTS OF THE RAT LUMBAR SPINE [J].

AHMED, M ;

BJURHOLM, A ;

KREICBERGS, A ;

SCHULTZBERG, M .

SPINE, 1993, 18 (02) :268-273

[3] Hypothalamic control of bone formation: Distinct actions of leptin and Y2 receptor pathways [J].

Baldock, PA ;

Sainsbury, A ;

Allison, S ;

Lin, EJD ;

Couzens, M ;

Boey, D ;

Enriquez, R ;

During, M ;

Herzog, H ;

Gardiner, EM .

JOURNAL OF BONE AND MINERAL RESEARCH, 2005, 20 (10) :1851-1857

[4] Hypothalamic Y2 receptors regulate bone formation [J].

Baldock, PA ;

Sainsbury, A ;

Couzens, M ;

Enriquez, RF ;

Thomas, GP ;

Gardiner, EM ;

Herzog, H .

JOURNAL OF CLINICAL INVESTIGATION, 2002, 109 (07) :915-921

[5] Hypothalamic regulation of cortical bone mass: Opposing activity of Y2 receptor and leptin pathways [J].

Baldock, Paul A. ;

Allison, Susan ;

McDonald, Michelle M. ;

Sainsbury, Amanda ;

Enriquez, Ronaldo F. ;

Little, David G. ;

Eisman, John A. ;

Gardiner, Edith M. ;

Herzog, Herbert .

JOURNAL OF BONE AND MINERAL RESEARCH, 2006, 21 (10) :1600-1607

[6] Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus [J].

Baskin, DG ;

Breininger, JF ;

Schwartz, MW .

DIABETES, 1999, 48 (04) :828-833

[7]

BJURHOLM A, 1991, INT ORTHOP, V15, P325

[8]

BJURHOLM A, 1992, J BONE MINER RES, V7, P1011

[9] Neuropeptides and their receptors: innovative science providing novel therapeutic targets [J].

Brain, SD ;

Cox, HM .

BRITISH JOURNAL OF PHARMACOLOGY, 2006, 147 :S202-S211

[10] Subtypes Y1 and Y2 of the neuropeptide Y receptor are respectively expressed in pro-opiomelanocortin- and neuropeptide-Y-containing neurons of the rat hypothalamic arcuate nucleus [J].

Broberger, C ;

Landry, M ;

Wong, H ;

Walsh, JN ;

Hokfelt, T .

NEUROENDOCRINOLOGY, 1997, 66 (06) :393-408

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