The control of bone remodeling by neuropeptide Y receptors

被引：34

作者：

Allison, S. J.

Baldock, P. A.

Herzog, H.

机构：

[1] St Vincents Hosp, Neurobiol Program, Garvan Inst Med Res, Sydney, NSW 2010, Australia

[2] St Vincents Hosp, Bone & Mineral Res Program, Garvan Inst Med Res, Sydney, NSW 2010, Australia

来源：

PEPTIDES | 2007年 / 28卷 / 02期

关键词：

bone remodeling; Y2; receptor; leptin; hypothalamus;

D O I：

10.1016/j.peptides.2006.05.029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An important role for the neuropeptide Y receptor system in the regulation of bone formation was recently revealed with a significant elevation in trabecular bone formation and bone volume following germline or hypothalamus-specific deletion of neuropeptide Y2 receptors in mice. Subsequent studies have now demonstrated that this central pathway is distinct from that of the other centrally regulated bone formation pathway mediated by leptin. This review discusses these recent findings and outlines how these new pathways could translate into potential novel targets for the treatment of bone disease. (c) 2006 Elsevier Inc. All rights reserved.

引用

收藏

页码：320 / 325

页数：6

相关论文

共 36 条

[11] Serum immunoreactive leptin concentrations in normal-weight and obese humans [J].

Considine, RV ;

Sinha, MK ;

Heiman, ML ;

Kriauciunas, A ;

Stephens, TW ;

Nyce, MR ;

Ohannesian, JP ;

Marco, CC ;

McKee, LJ ;

Bauer, TL ;

Caro, JF .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (05) :292-295

[12] Leptin inhibits bone formation through a hypothalamic relay: A central control of bone mass [J].

Ducy, P ;

Amling, M ;

Takeda, S ;

Priemel, M ;

Schilling, AF ;

Beil, FT ;

Shen, JH ;

Vinson, C ;

Rueger, JM ;

Karsenty, G .

CELL, 2000, 100 (02) :197-207

[13] Leptin regulation of bone resorption by the sympathetic nervous system and CART [J].

Elefteriou, F ;

Ahn, JD ;

Takeda, S ;

Starbuck, M ;

Yang, XL ;

Liu, XY ;

Kondo, H ;

Richards, WG ;

Bannon, TW ;

Noda, M ;

Clement, K ;

Vaisse, C ;

Karsenty, G .

NATURE, 2005, 434 (7032) :514-520

[14] Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y [J].

Erickson, JC ;

Hollopeter, G ;

Palmiter, RD .

SCIENCE, 1996, 274 (5293) :1704-1707

[15] DETECTION OF NEUROPEPTIDE-Y AND ITS MESSENGER-RNA IN MEGAKARYOCYTES - ENHANCED LEVELS IN CERTAIN AUTOIMMUNE MICE [J].

ERICSSON, A ;

SCHALLING, M ;

MCINTYRE, KR ;

LUNDBERG, JM ;

LARHAMMAR, D ;

SEROOGY, K ;

HOKFELT, T ;

PERSSON, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (16) :5585-5589

[16] EFFECTS OF NEONATAL SYMPATHECTOMY AND CAPSAICIN TREATMENT ON BONE REMODELING IN RATS [J].

HILL, EL ;

TURNER, R ;

ELDE, R .

NEUROSCIENCE, 1991, 44 (03) :747-755

[17] Formoterol and isoproterenol induce c-fos gene expression in osteoblast-like cells by activating β2-adrenergic receptors [J].

Kellenberger, S ;

Muller, K ;

Richener, H ;

Bilbe, G .

BONE, 1998, 22 (05) :471-478

[18] Effect of a selective neuropeptide YY2 receptor antagonist, BIIE0246 on neuropeptide Y release [J].

King, PJ ;

Williams, G ;

Doods, H ;

Widdowson, PS .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2000, 396 (01) :R1-R3

[19] VASOCONSTRICTIVE ACTION OF NEUROPEPTIDE-Y IN BONE - THE PORCINE TIBIA PERFUSED IN-VIVO [J].

LINDBLAD, BE ;

NIELSEN, LB ;

JESPERSEN, SM ;

BJURHOLM, A ;

BUNGER, C ;

HANSEN, ES .

ACTA ORTHOPAEDICA SCANDINAVICA, 1994, 65 (06) :629-634

[20] Sex steroids and bone [J].

Manolagas, SC ;

Kousteni, S ;

Jilka, RL .

RECENT PROGRESS IN HORMONE RESEARCH, VOL 57: REPRODUCTIVE HORMONES & HUMAN HEALTH, 2002, 57 :385-409

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