CXC-chemokines KC and macrophage inflammatory protein-2 (MIP-2) synergistically induce leukocyte recruitment to the central nervous system in rats

被引：46

作者：

Zwijnenburg, PJG ^{[1
]}

Polfliet, MMJ

Florquin, S

van den Berg, TK

Dijkstra, CD

van Deventer, SJH

Roord, JJ

van der Poll, T

van Furth, AM

机构：

[1] Vrije Univ Amsterdam, Med Ctr, Dept Pediat, Amsterdam, Netherlands

[2] Vrije Univ Amsterdam, Med Ctr, Dept Mol Cell Biol, Amsterdam, Netherlands

[3] Univ Amsterdam, Acad Med Ctr, Dept Expt Internal Med, NL-1105 AZ Amsterdam, Netherlands

[4] Univ Amsterdam, Acad Med Ctr, Dept Pathol, NL-1105 AZ Amsterdam, Netherlands

来源：

IMMUNOLOGY LETTERS | 2003年 / 85卷 / 01期

关键词：

KC; MIP-2; central nervous system;

D O I：

10.1016/S0165-2478(02)00200-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Intracisternal injection of the CXC-chemokines KC or macrophage inflammatory protein (MIP)-2 induced a pleocytosis in the cerebrospinal fluid (CSF) of rats in a dose dependent way. MIP-2 was much more potent than KC. The concurrent injection of both chemokines revealed a profound synergistic effect on leukocyte recruitment into CSF. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：1 / 4

页数：4

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