A new inbred strain JF1 established from Japanese fancy mouse carrying the classic piebald allele

被引:102
作者
Koide, T
Moriwaki, K
Uchida, K
Mita, A
Sagai, T
Yonekawa, H
Katoh, H
Miyashita, N
Tsuchiya, K
Nielsen, TJ
Shiroishi, T
机构
[1] Natl Inst Genet, Mammalian Genet Lab, Shizuoka 411, Japan
[2] Grad Univ Adv Studies, Kanagawa 24001, Japan
[3] Tokyo Metropolitan Inst Med Sci, Dept Lab Anim Sci, Tokyo 113, Japan
[4] Cent Inst Expt Anim, Kawasaki, Kanagawa 216, Japan
[5] Kagawa Med Univ, Expt Anim Ctr, Kagawa 76107, Japan
[6] Miyazaki Med Coll, Expt Anim Ctr, Miyazaki 88916, Japan
[7] Aarhus Univ, DK-8000 Aarhus C, Denmark
关键词
D O I
10.1007/s003359900672
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A new inbred strain JF1 (Japanese Fancy Mouse 1) was established from a strain of fancy mouse. Morphological and genetical analysis indicated that the mouse originated from the Japanese wild mouse, Mus musculus molossinus. JF1 has characteristic coat color, black spots on the white coat, with black eyes. The mutation appeared to be linked to an old mutation piebald (s). Characterization of the causative gene for piebald, endothelin receptor type B (ednrb), demonstrated that the allele in JF1 is same as that of classic piebald allele, suggesting an identical origin of these two mutants. Possibly, classic piebald mutation was introduced from the Japanese tame mouse, which was already reported at the end of the 1700s. We showed that JF1 is a useful strain for mapping of mutant genes on laboratory strains owing to a high level of polymorphisms in microsatellite markers between JF1 and laboratory strains. The clarified genotypes of JF1 for coat color are "aa BE CC DD ss".
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页码:15 / 19
页数:5
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共 26 条
  • [1] MOST CLASSICAL MUS-MUSCULUS-DOMESTICUS LABORATORY MOUSE STRAINS CARRY A MUS-MUSCULUS-MUSCULUS Y-CHROMOSOME
    BISHOP, CE
    BOURSOT, P
    BARON, B
    BONHOMME, F
    HATAT, D
    [J]. NATURE, 1985, 315 (6014) : 70 - 72
  • [2] BONHOMME F, 1996, GENETIC VARIANTS STR, P1577
  • [3] BRILLIANT MH, 1994, GENETICS, V138, P203
  • [4] Darbishire AD, 1904, BIOMETRIKA, V3, P1
  • [5] Darbishire AD, 1902, BIOMETRIKA, V2, P282
  • [6] Darbishire AD, 1902, BIOMETRIKA, V2, P101, DOI 10.2307/2331502
  • [7] FERRIS SD, 1983, GENETICS, V105, P681
  • [8] FOSTER HL, 1981, MOUSE BIOMEDICAL RES, V1
  • [9] Gates W. H., 1926, CONTRIBUTIONS KNOWLE, P83
  • [10] TARGETED AND NATURAL (PIEBALD-LETHAL) MUTATIONS OF ENDOTHELIN-B RECEPTOR GENE PRODUCE MEGACOLON ASSOCIATED WITH SPOTTED COAT COLOR IN MICE
    HOSODA, K
    HAMMER, RE
    RICHARDSON, JA
    BAYNASH, AG
    CHEUNG, JC
    GIAID, A
    YANAGISAWA, M
    [J]. CELL, 1994, 79 (07) : 1267 - 1276