Triplex-directed modification of genes and gene activity

被引：168

作者：

Vasquez, KM ^{[1
]}

Wilson, JH

机构：

[1] Yale Univ, Sch Med, Dept Therapeut Radiol, New Haven, CT 06510 USA

[2] Baylor Coll Med, Verna & Marrs Mclean Dept Biochem, Houston, TX 77030 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1998年 / 23卷 / 01期

关键词：

D O I：

10.1016/S0968-0004(97)01158-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oligonucleotides offer enormous potential for manipulating gene function in cells and, as such, constitute a promising new class of pharmaceutical agents. Oligonucleotides that form triple helices (triplexes) at specific DNA sequences in defined genes can be used to reduce transcription selectively, to introduce site-specific mutations or to stimulate gene-specific targeted recombination.

引用

页码：4 / 9

页数：6

共 49 条

[1]

Aggarwal BB, 1996, CANCER RES, V56, P5156

[2] 2ND STRUCTURAL MOTIF FOR RECOGNITION OF DNA BY OLIGONUCLEOTIDE-DIRECTED TRIPLE-HELIX FORMATION [J].

BEAL, PA ;

DERVAN, PB .

SCIENCE, 1991, 251 (4999) :1360-1363

[3] AN OVERABUNDANCE OF LONG OLIGOPURINE TRACTS OCCURS IN THE GENOME OF SIMPLE AND COMPLEX EUKARYOTES [J].

BEHE, MJ .

NUCLEIC ACIDS RESEARCH, 1995, 23 (04) :689-695

[4] ALTERING THE GENOME BY HOMOLOGOUS RECOMBINATION [J].

CAPECCHI, MR .

SCIENCE, 1989, 244 (4910) :1288-1292

[5] Triplex DNA: Fundamentals, advances, and potential applications for gene therapy [J].

Chan, PP ;

Glazer, PM .

JOURNAL OF MOLECULAR MEDICINE-JMM, 1997, 75 (04) :267-282

[6] Specificity of antiparallel DNA triple helix formation [J].

Chandler, SP ;

Fox, KR .

BIOCHEMISTRY, 1996, 35 (47) :15038-15048

[7] SITE-SPECIFIC OLIGONUCLEOTIDE BINDING REPRESSES TRANSCRIPTION OF THE HUMAN C-MYC GENE INVITRO [J].

COONEY, M ;

CZERNUSZEWICZ, G ;

POSTEL, EH ;

FLINT, SJ ;

HOGAN, ME .

SCIENCE, 1988, 241 (4864) :456-459

[8] Investigation of the formation and intracellular stability of purine (puuine/pyrimidine) triplexes [J].

Debin, A ;

Malvy, C ;

Svinarchuk, F .

NUCLEIC ACIDS RESEARCH, 1997, 25 (10) :1965-1974

[9]

DEGOLS G, 1994, J BIOL CHEM, V269, P16933

[10] TRIPLEX FORMATION INHIBITS HER-2 NEU TRANSCRIPTION IN-VITRO [J].

EBBINGHAUS, SW ;

GEE, JE ;

RODU, B ;

MAYFIELD, CA ;

SANDERS, G ;

MILLER, DM .

JOURNAL OF CLINICAL INVESTIGATION, 1993, 92 (05) :2433-2439

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