The stem cell niche: theme and variations

被引：238

作者：

Ohlstein, B ^{[1
]}

Kai, T ^{[1
]}

Decotto, E ^{[1
]}

Spradling, A ^{[1
]}

机构：

[1] Carnegie Inst Sci, Dept Embryol, Howard Hughes Med Inst, Baltimore, MD 21210 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2004年 / 16卷 / 06期

关键词：

D O I：

10.1016/j.ceb.2004.09.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Stem cells in animal tissues are often located and controlled by special tissue microenvironments known as niches. Studies of stem cell niches in model systems such as Drosophila have revealed adhesive interactions, cell cycle modifications and intercellular signals that operate to control stem cell behavior. Candidate niches and regulatory molecules have also been identified in many mammalian tissues, including bone marrow, skin, gut and brain. While niches are an ancient evolutionary device with conserved features across diverse organisms, we suggest that certain niches display important differences in their organization and function.

引用

页码：693 / 699

页数：7

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