Lack of effect of gastric acid-reducing agents on the pharmacokinetics of lopinavir/ritonavir in HIV-infected patients

被引：10

作者：

Chiu, Yi-Lin ^{[1
]}

Klein, Cheri E. ^{[1
]}

Woodward, William C. ^{[1
]}

King, Kathryn R. ^{[1
]}

Naylor, Christian ^{[1
]}

Awni, Walid ^{[1
]}

Brun, Scott ^{[1
]}

机构：

[1] Abbott Labs, Abbott Pk, IL 60064 USA

来源：

AIDS PATIENT CARE AND STDS | 2007年 / 21卷 / 04期

关键词：

PROTON-PUMP INHIBITORS; DRUG-INTERACTIONS; ATAZANAVIR; OMEPRAZOLE; VOLUNTEERS; RITONAVIR; REGIMEN;

D O I：

10.1089/apc.2006.0120

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Recent studies have shown that coadministration of certain protease inhibitors (PIs) with gastric acid-reducing agents results in decreased plasma concentrations of the PI. To assess the effect of acid-reducing agents on lopinavir/ritonavir, data from two clinical trials ( n = 38 and 190) were pooled. Both trials randomized antiretroviral-naive, HIV-infected patients to receive lopinavir/ritonavir 400/100 mg twice-daily or 800/200 mg once-daily in combination with stavudine and lamivudine, or tenofovir and emtricitabine. Concurrent administration of gastric acid-reducing agents including antacids of various brand names, proton pump inhibitors (omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole), and H-2-receptor antagonists (ranitidine, famotidine, cimetidine, and nizatidine) was reported in both trials. Lopinavir and ritonavir pharmacokinetic parameters were evaluated. Thirty subjects were considered users of acid-reducing agents at the times of pharmacokinetic evaluation. HIV-infected patients who received gastric acid-reducing agents during administration of lopinavir/ritonavir-based treatment regimens did not appear to have a reduction in lopinavir or ritonavir exposures.

引用

页码：247 / 251

页数：5

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