An ancient system of host defense

被引：255

作者：

Medzhitov, R

Janeway, CA

机构：

[1] Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06520 USA

[2] Howard Hughes Med Inst, New Haven, CT 06520 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1998年 / 10卷 / 01期

关键词：

D O I：

10.1016/S0952-7915(98)80024-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Research over the past few years has begun to provide significant advances in our understanding of the interplay between the innate and adaptive immune systems. New findings in several model systems reveal remarkable parallels and conservation of ancient host defense pathways in organisms separated by over a billion years of evolution.

引用

收藏

页码：12 / 15

页数：4

相关论文

共 31 条

[1]

Baker SJ, 1996, ONCOGENE, V12, P1

[2] A conserved signaling pathway: The Drosophila Toll-Dorsal pathway [J].

Belvin, MP ;

Anderson, KV .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1996, 12 :393-416

[3] The cloning and characterization of human MyD88: A member of an IL-1 receptor related family [J].

Bonnert, TP ;

Garka, KE ;

Parnet, P ;

Sonoda, G ;

Testa, JR ;

Sims, JE .

FEBS LETTERS, 1997, 402 (01) :81-84

[4] IRAK: A kinase associated with the interleukin-1 receptor [J].

Cao, ZD ;

Henzel, WJ ;

Gao, XO .

SCIENCE, 1996, 271 (5252) :1128-1131

[5] Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila [J].

Dushay, MS ;

Asling, B ;

Hultmark, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (19) :10343-10347

[6]

ELDON E, 1994, DEVELOPMENT, V120, P885

[7] KAPPA-B-LIKE MOTIFS REGULATE THE INDUCTION OF IMMUNE GENES IN DROSOPHILA [J].

ENGSTROM, Y ;

KADALAYIL, L ;

SUN, SC ;

SAMAKOVLIS, C ;

HULTMARK, D ;

FAYE, I .

JOURNAL OF MOLECULAR BIOLOGY, 1993, 232 (02) :327-333

[8] Elements of immunity - The instructive role of innate immunity in the acquired immune response [J].

Fearon, DT ;

Locksley, RM .

SCIENCE, 1996, 272 (5258) :50-54

[9] INSECT IMMUNITY - THE DIPTERICIN PROMOTER CONTAINS MULTIPLE FUNCTIONAL REGULATORY SEQUENCES HOMOLOGOUS TO MAMMALIAN ACUTE-PHASE RESPONSE ELEMENTS [J].

GEORGEL, P ;

MEISTER, M ;

KAPPLER, C ;

LEMAITRE, B ;

REICHHART, JM ;

HOFFMANN, JA .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 197 (02) :508-517

[10] Plant disease resistance genes [J].

HammondKosack, KE ;

Jones, JDG .

ANNUAL REVIEW OF PLANT PHYSIOLOGY AND PLANT MOLECULAR BIOLOGY, 1997, 48 :575-607

← 1 2 3 4 →