Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7

被引:65
作者
Kalman, K
Nguyen, A
Tseng-Crank, J
Dukes, ID
Chandy, G
Hustad, CM
Copeland, NG
Jenkins, NA
Mohrenweiser, H
Brandriff, B
Cahalan, M
Gutman, GA
Chandy, KG
机构
[1] Univ Calif Irvine, Sch Med, Dept Physiol & Biophys, Irvine, CA 92697 USA
[2] Univ Calif Irvine, Dept Microbiol & Mol Genet, Irvine, CA 92697 USA
[3] Glaxo Wellcome Res Inst, Res Triangle Pk, NC 27709 USA
[4] NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program, Mammalian Genet Lab, Frederick, MD 21702 USA
[5] Univ Calif Lawrence Livermore Natl Lab, Ctr Human Genome, Livermore, CA 94550 USA
关键词
D O I
10.1074/jbc.273.10.5851
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We report the isolation of a novel mouse voltage-gated Shaker-related K+ channel gene, Kv1.7 (Kcna7/KCNA7). Unlike other known Kv1 family genes that have intronless coding regions, the protein-coding region of Ku1.7 is interrupted by a 1,9-kilobase pair intron, The Kv1.7 gene and the related Kv3.3 (Kcnc3/KCNC3) gene map to mouse chromosome 7 and human chromosome 19q13.3, a region that has been suggested to contain a diabetic susceptibility locus, The mouse Kv1,7 channel is voltage-dependent and rapidly inactivating, exhibits cumulative inactivation, and has a single channel conductance of 21 pS, It is potently blocked by noxiustoxin and stichodactylatoxin, and is insensitive to tetraethylammonium, kaliotoxin, and charybdotoxin. Northern blot analysis reveals similar to 3-kilobase pair Kv1.7 transcripts in mouse heart and skeletal muscle, In situ hybridization demonstrates the presence of Kv1.7 in mouse pancreatic islet cells. Kv1.7 was also isolated from mouse brain and hamster insulinoma cells by polymerase chain reaction.
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收藏
页码:5851 / 5857
页数:7
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