Improved antimicrobial peptides based on acyl-lysine oligomers

被引：224

作者：

Radzishevsky, Inna S.

Rotem, Shahar

Bourdetsky, Dmitry

Navon-Venezia, Shiri

Carmeli, Yehuda

Mor, Amram ^{[1
]}

机构：

[1] Technion Israel Inst Technol, Dept Food Engn & Biotechnol, IL-32000 Haifa, Israel

[2] Tel Aviv Sourasky Med Ctr, Div Epidemiol, IL-64239 Tel Aviv, Israel

来源：

NATURE BIOTECHNOLOGY | 2007年 / 25卷 / 06期

基金：

以色列科学基金会;

关键词：

D O I：

10.1038/nbt1309

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We describe peptidomimetic oligomers that show rapid, nonhemolytic, broad-spectrum bactericidal properties in mice and do not induce the emergence of resistance. The oligomers contain acyl chains, which prevent the formation of stable secondary structure. This design appears advantageous over conventional antimicrobial peptides with respect to in vivo efficacy and safety, and may provide a convenient platform for the development of peptide antibiotics.

引用

收藏

页码：657 / 659

页数：3

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