Influence of reduced susceptibility to glycopeptides on activities of vancomycin and teicoplanin against Staphylococcus aureus in experimental endocarditis

被引：12

作者：

Pavie, J

Lefort, A

Ploy, MC

Massias, L

Chau, F

Garry, L

Denis, F

Fantin, B

机构：

[1] Univ Paris 07, INSERM, EMI U 9933, F-75018 Paris, France

[2] Hop Xavier Bichat, Serv Pharm, F-75018 Paris, France

[3] CHU Limoges, Microbiol Lab, F-87042 Limoges, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 06期

关键词：

D O I：

10.1128/AAC.47.6.2018-2021.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The influence of reduced susceptibilities to glycopeptides on the activities of vancomycin and teicoplanin against an isogenic pair of clinical Staphylococcus aureus strains in experimental endocarditis was investigated. While vancomycin was similarly active against both strains, teicoplanin was approximately 100-fold less active against the resistant strain and selected for the emergence of more resistant subpopulations.

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页码：2018 / 2021

页数：4

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