Treatment of Chronic Lymphocytic Leukemia With Genetically Targeted Autologous T Cells: Case Report of an Unforeseen Adverse Event in a Phase I Clinical Trial

被引：315

作者：

Brentjens, Renier ^{[1
]}

Yeh, Raymond ^{[1
]}

Bernal, Yvette ^{[1
]}

Riviere, Isabelle ^{[1
]}

Sadelain, Michel ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

来源：

MOLECULAR THERAPY | 2010年 / 18卷 / 04期

关键词：

TUMORS;

D O I：

10.1038/mt.2010.31

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

引用

页码：666 / 668

页数：3

共 6 条

[1] Genetically targeted T cells eradicate systemic acute lymphoblastic leukemia xenografts
Brentjens, Renier J.
Santos, Elmer
Nikhamin, Yan
Yeh, Raymond
Matsushita, Maiko
La Perle, Krista
Quintas-Cardama, Alfonso
Larson, Steven M.
Sadelain, Michel
[J]. CLINICAL CANCER RESEARCH, 2007, 13 (18) : 5426 - 5435
[2] Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15
Brentjens, RJ
Latouche, JB
Santos, E
Marti, F
Gong, MC
Lyddane, C
King, PD
Larson, S
Weiss, M
Rivière, I
Sadelain, M
[J]. NATURE MEDICINE, 2003, 9 (03) : 279 - 286
[3] Manufacturing Validation of Biologically Functional T Cells Targeted to CD19 Antigen for Autologous Adoptive Cell Therapy
Hollyman, Daniel
Stefanski, Jolanta
Przybylowski, Mark
Bartido, Shirley
Borquez-Ojeda, Oriana
Taylor, Clare
Yeh, Raymond
Capacio, Vanessa
Olszewska, Malgorzata
Hosey, James
Sadelain, Michel
Brentjens, Renier J.
Riviere, Isabelle
[J]. JOURNAL OF IMMUNOTHERAPY, 2009, 32 (02) : 169 - 180
[4] Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRζ/CD28 receptor
Maher, J
Brentjens, RJ
Gunset, G
Rivière, I
Sadelain, M
[J]. NATURE BIOTECHNOLOGY, 2002, 20 (01) : 70 - 75
[5] Targeting tumours with genetically enhanced T lymphocytes
Sadelain, M
Rivière, I
Brentjens, R
[J]. NATURE REVIEWS CANCER, 2003, 3 (01) : 35 - 45
[6] The promise and potential pitfalls of chimeric antigen receptors
Sadelain, Michel
Brentjens, Renier
Riviere, Isabelle
[J]. CURRENT OPINION IN IMMUNOLOGY, 2009, 21 (02) : 215 - 223

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