Therapeutically targeting SELF-reinforcing leukemic niches in acute myeloid leukemia: A worthy endeavor?

被引：19

作者：

Bernasconi, Paolo ^{[1
]}

Farina, Mirko ^{[1
]}

Boni, Marina ^{[1
]}

Dambruoso, Irene ^{[1
]}

Calvello, Celeste ^{[1
]}

机构：

[1] Univ Pavia, Div Hematol, Fdn IRCCS Policlin San Matteo, I-27100 Pavia, Italy

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 2016年 / 91卷 / 05期

关键词：

HEMATOPOIETIC STEM-CELL; MEDIATED DRUG-RESISTANCE; NF-KAPPA-B; BONE-MARROW; IN-VIVO; AML CELLS; ENDOTHELIAL-CELLS; PROGNOSTIC-FACTOR; ANTICANCER DRUG; GROWTH-FACTORS;

D O I：

10.1002/ajh.24312

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

A tight relationship between the acute myeloid leukemia (AML) population and the bone marrow (BM) microenvironment has been convincingly established. The AML clone contains leukemic stem cells (LSCs) that compete with normal hematopoietic stem cells (HSCs) for niche occupancy and remodel the niche; whereas, the BM microenvironment might promote AML development and progression not only through hypoxia and homing/adhesion molecules, but also through genetic defects. Although it is still unknown whether the niche influences treatment results or contains any potential target for treatment, this dynamic AML-niche interaction might be a promising therapeutic objective to significantly improve the AML cure rate. Am. J. Hematol. 91:507-517, 2016. (c) 2016 Wiley Periodicals, Inc.

引用

页码：507 / 517

页数：11

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