New flavans, spirostanol sapogenins, and a pregnane genin from Tupistra chinensis and their cytotoxicity

被引：72

作者：

Pan, WB ^{[1
]}

Chang, FR ^{[1
]}

Wei, LM ^{[1
]}

Wu, YC ^{[1
]}

机构：

[1] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 02期

关键词：

D O I：

10.1021/np0203382

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Seven new compounds, including three new flavans [tupichinol A-C (1-3)], three new spirostanol sapogenins [tupichigenin D-F (4-6)], and one new pregnane genin [tupipregnenolone (7)], together with 18 known compounds, were isolated from the underground parts of Tupistra chinensis. The structures of the new compounds were elucidated by spectroscopic analysis and chemical evidence. The structures and relative stereochemistry of 1 and 9 were further confirmed by single-crystal X-ray crystallographic analysis. Compounds Delta(25(27))-pentrogenin, 10, and ranmogenin A showed 100%, 96%, and 80% inhibition, respectively, against human gastric tumor (NUGC) cells at a concentration of 50 muM. Delta(25(27))-pentrogenin showed 100% inhibition against human nasopharyngeal carcinoma (HONE-1) cells at a concentration of 50 muM.

引用

页码：161 / 168

页数：8

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