Ising-like model for protein mechanical unfolding

被引：59

作者：

Imparato, A.

Pelizzola, A.

Zamparo, M.

机构：

[1] Politecn Torino, Dipartimento Fis, I-10129 Turin, Italy

[2] Politecn Torino, CNISM, I-10129 Turin, Italy

[3] Ist Nazl Fis Nucl, Sez Turin, I-10125 Turin, Italy

来源：

PHYSICAL REVIEW LETTERS | 2007年 / 98卷 / 14期

关键词：

D O I：

10.1103/PhysRevLett.98.148102

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

The mechanical unfolding of proteins is studied by extending the Wako-Saito-Munoz-Eaton model. This model is generalized by including an external force, and its thermodynamics turns out to be exactly solvable. We consider two molecules, the 27th immunoglobulin domain of titin and protein PIN1. We determine equilibrium force-extension curves for the titin and study the mechanical unfolding of this molecule, finding good agreement with experiments. By using an extended form of the Jarzynski equality, we compute the free energy landscape of the PIN1 as a function of the molecule length.

引用

页数：4

共 33 条

[1] Analyses of simulations of three-dimensional lattice proteins in comparison with a simplified statistical mechanical model of protein folding [J].