Sodium selenate corrects glucose tolerance and heart function in STZ diabetic rats

被引：59

作者：

Battell, ML ^{[1
]}

Delgatty, HLM ^{[1
]}

McNeill, JH ^{[1
]}

机构：

[1] Univ British Columbia, Fac Pharmaceut Sci, Div Pharmacol & Toxicol, Vancouver, BC V6T 1Z3, Canada

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 1998年 / 179卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

diabetes; selenium; insulin-like; heart function;

D O I：

10.1023/A:1006819227506

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Sodium selenate, administered intraperitoneally (i.p.), resulted in an improvement in glucose tolerance in treated diabetic rats. Fed rat plasma glucose levels were reduced by selenate treatment in streptozotocin diabetic rats. The lowest values of blood glucose were reached within 3 weeks of beginning the treatment. Food and fluid consumption was reduced in treated compared to untreated diabetic rats. Diabetic treated rats did not release insulin in response to a glucose challenge and insulin release in response to a challenge was markedly reduced in control treated rats. Assessment of heart function using a working heart apparatus showed that treated diabetic rats with improved blood glucose levels had normal heart function at 8 weeks of diabetes in contrast to hearts from non-treated diabetics. This study extends previous observations on the in vivo insulin-like effects of sodium selenate.

引用

页码：27 / 34

页数：8

共 38 条

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