Sequence-selective molecular recognition between β sheets

被引：32

作者：

Nowick, JS ^{[1
]}

Chung, DM ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Chem, Irvine, CA 92697 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 15期

关键词：

beta sheets; molecular recognition; peptides; proteins; supramolecular chemistry;

D O I：

10.1002/anie.200250750

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Molecular recognition between peptide β sheets is sequence selective! By simply controlling the placement of two threonine (Thr) or valine (Val) residues, peptides that preferentially form either homodimers or heterodimers with about tenfold selectivity can be generated. The picture shows the structure of a Thr-Val·Val-Thr heterodimer.

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收藏

页码：1765 / 1768

页数：4

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