Survival of invasive breast cancer according to the Nottingham Prognostic Index in cases diagnosed in 1990-1999

被引：148

作者：

Blamey, R. W. ^{[1
]}

Ellis, I. O.

Pinder, S. E.

Lee, A. H. S.

Macmillan, R. D.

Morgan, D. A. L.

Robertson, J. F. R.

Mitchell, M. J.

Ball, G. R.

Haybittle, J. L.

Elston, C. W.

机构：

[1] City Hosp Nottingham, Breast Inst, Nottingham NG5 1PB, England

[2] Nottingham Trent Univ, Sch Biomed & Nat Sci, Nottingham, England

来源：

EUROPEAN JOURNAL OF CANCER | 2007年 / 43卷 / 10期

关键词：

breast cancer; prognosis; prognostic index; case survival; improved surgery;

D O I：

10.1016/j.ejca.2007.01.016

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Nottingham Prognostic Index (NPI) is a well established and widely used method of predicting survival of operable primary breast cancer. Aims: Primary: To present the updated survival figures for each NPI Group. Secondary: From the observations to suggest reasons for the reported fall in mortality from breast cancer. Methods: The NPI is compiled from grade, size and lymph node status of the primary tumour. Consecutive cases diagnosed and treated at Nottingham City Hospital in 1980- 1986 (n = 892) and 1990-1999 (n = 2238) are compared. Changes in protocols towards earlier diagnosis and better case management were made in the late 1980s between the two data sets. Results: Case survival (Breast Cancer Specific) at 10 years has improved overall from 55% to 77%. Within all Prognostic groups there are high relative and absolute risk reductions. The distribution of cases to Prognostic groups shows only a small increase in the numbers in better groups. Conclusion: The updated survival figures overall and for each Prognostic group for the NPI are presented. (C) 2007 Published by Elsevier Ltd.

引用

页码：1548 / 1555

页数：8

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