Signal transduction in environmental neurotoxicity

Signal transduction is the process by which specific information is transferred from the cell surface to the cytosol and ultimately to the nucleus, leading to changes in gene expression. Since these chains of biochemical and molecular steps control the normal function of each cell, disruption of these processes would have a significant impact on cell physiology. Some of the major signal transduction pathways are briefly reviewed. The interactions of four chemicals (lead, ethanol, polychlorinated biphenyls, and trimethyltin) with different cell signaling systems, particularly the phospholipid hydrolysis/protein kinase C pathway, are discussed. The possible causal relationship of such cellular and molecular interactions with known signs and symptoms of neurotoxicity are highlighted.