EEG-fMRI in children with pharmacoresistant focal epilepsy

被引：37

作者：

De Tiege, Xavier

Laufs, Helmut

Boyd, Stewart G.

Harkness, William

Allen, Philip J.

Clark, Chris A.

Connelly, Alan

Cross, J. Helen

机构：

[1] UCL, Neurosci Unit, Inst Child Hlth, London, England

[2] UCL, Radiol & Phys Unit, Inst Child Hlth, London, England

[3] Great Ormond St Hosp Sick Children, Dept Clin Neurophysiol, London WC1N 3JH, England

[4] Great Ormond St Hosp Sick Children, Dept Neurosurg, London WC1N 3JH, England

[5] UCL Inst Neurol, Natl Soc Epilepsy, London, England

[6] UCL Inst Neurol, Dept Clin & Expt Epilepsy, London, England

[7] UCL Inst Neurol, Dept Clin Neurophysiol, London, England

来源：

EPILEPSIA | 2007年 / 48卷 / 02期

关键词：

EEG-fMRI; focal epilepsy; pharmacoresistant epilepsy; surgery; children;

D O I：

10.1111/j.1528-1167.2006.00951.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Purpose: To evaluate the usefulness of EEG-combined functional magnetic resonance imaging (EEG-fMRI) to localize epileptogenic sources. Methods: Six children (age 8-15 years) with lesional or nonlesional pharmacoresistant focal epilepsy were studied. Results: We found significant activations in four children, activation and deactivation in one child, and widespread deactivation in another. In four children, activations colocalized with the presumed location of the epileptic focus, one of which was confirmed by intracranial EEG. Conclusions: EEG-fMRI is a promising tool to noninvasively localize epileptogenic regions in children with pharmacoresistant focal epilepsy.

引用

页码：385 / 389

页数：5

共 11 条

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