Transposable elements in gene regulation and in the evolution of vertebrate genomes

被引：115

作者：

Bourque, Guillaume ^{[1
]}

机构：

[1] Genome Inst Singapore, Singapore 138672, Singapore

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2009年 / 19卷 / 06期

关键词：

FACTOR-BINDING-SITES; SEGMENTAL DUPLICATIONS; STRUCTURAL VARIATION; MONODELPHIS-DOMESTICA; SEQUENCES; REPEAT; DNA; RETROTRANSPOSONS; CLASSIFICATION; IDENTIFICATION;

D O I：

10.1016/j.gde.2009.10.013

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Repetitive DNA and in particular transposable elements have been intimately linked to eukaryotic genomes for millions of years. Once overlooked for being only a collection of selfish debris and a nuisance for sequence assembly, genomic repeats are now being recognized as a key driving force in genome evolution. Indeed, by changing the DNA landscape of genomes, transposable elements have been a rich source of innovation in genes, regulatory elements and genome structures. In this review, I will focus on recent advances that demonstrate that genomic repeats have had a global impact on vertebrate gene regulatory networks. I will also summarize results that show how transposable elements have been a major catalyst of structural rearrangements throughout evolution.

引用

页码：607 / 612

页数：6

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