Host-parasite coevolutionary conflict between Arabidopsis and downy mildew

被引:325
作者
Allen, RL
Bittner-Eddy, PD
Grenvitte-Briggs, LJ
Meitz, JC
Rehmany, AP
Rose, LE
Beynon, JL [1 ]
机构
[1] HRI Univ Warwick, Warwick CV35 9EF, England
[2] Univ Munich, Dept Evolutionary Biol, D-82152 Planegg Martinsried, Germany
基金
英国生物技术与生命科学研究理事会;
关键词
D O I
10.1126/science.1104022
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Plants are constantly exposed to attack by an array of diverse pathogens but lack a somatically adaptive immune system. In spite of this, natural plant populations do not often suffer destructive disease epidemics. Elucidating how allelic diversity within plant genes that function to detect pathogens (resistance genes) counteracts changing structures of pathogen genes required for host invasion (pathogenicity effectors) is critical to our understanding of the dynamics of natural plant populations. The RPP13 resistance gene is the most polymorphic gene analyzed to date in the model plant Arabidopsis thaliana. Here we report the cloning of the avirulence gene, ATR13, that triggers RPP13-mediated resistance, and we show that it too exhibits extreme levels of amino acid polymorphism. Evidence of diversifying selection visible in both components suggests that the host and pathogen may be locked in a coevolutionary conflict at these loci, where attempts to evade host resistance by the pathogen are matched by the development of new detection capabilities by the host.
引用
收藏
页码:1957 / 1960
页数:4
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