Targeted delivery of low molecular drugs using chitosan and its derivatives

被引:605
作者
Park, Jae Hyung [2 ,3 ]
Saravanakumar, Gurusamy [2 ]
Kim, Kwangmeyung [1 ]
Kwon, Ick Chan [1 ]
机构
[1] Korea Inst Sci & Technol, Biomed Res Ctr, Seoul 136791, South Korea
[2] Kyung Hee Univ, Dept Adv Polymer & Fiber Mat, Yongin 446701, Gyeonggi Do, South Korea
[3] Kyung Hee Univ, Dept Life & Nanopharmaceut Sci, Seoul 130701, South Korea
关键词
Chitosan; Low molecular drugs; Targeted delivery; SELF-ASSEMBLED NANOPARTICLES; MODIFIED GLYCOL CHITOSAN; N-SUCCINYL-CHITOSAN; COLON-SPECIFIC DELIVERY; O-SULFATE CHITOSAN; POLYION COMPLEX MICELLES; TRANS-RETINOIC ACID; IN-VITRO EVALUATION; POLYELECTROLYTE COMPLEXES; POLYMERIC MICELLES;
D O I
10.1016/j.addr.2009.10.003
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Chitosan has prompted the continuous impetus for the development of safe and effective drug delivery systems because of its unique physicochemical and biological characteristics. The primary hydroxyl and amine groups located on the backbone of chitosan allow for chemical modification to control its physical properties. When the hydrophobic moiety is conjugated to a chitosan molecule, the resulting amphiphile may form self-assembled nanoparticles that can encapsulate a quantity of drugs and deliver them to a specific site of action. Chemical attachment of the drug to the chitosan throughout the functional linker may produce useful prodrugs, exhibiting the appropriate biological activity at the target site. Mucoadhesive and absorption enhancement properties of chitosan increase the in vivo residence time of the dosage form in the gastrointestinal tract and improve the bioavailability of various drugs. The main objective of this review is to provide an insight into various target-specific carriers, based on chitosan and its derivatives, towards low molecular weight drug delivery. The first part of the review is concerned with the organ-specific delivery of low molecular drugs using chitosan and its derivatives. The subsequent section considers the recent developments of drug delivery carriers for cancer therapy with special focus on various targeting strategies. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码:28 / 41
页数:14
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