Alternative 5′-exons of the mouse cAMP-dependent protein kinase subunit RIα gene are conserved and expressed in both a ubiquitous and tissue-restricted fashion

被引：17

作者：

Barradeau, S ^{[1
]}

Imaizumi-Scherrer, T ^{[1
]}

Weiss, MC ^{[1
]}

Faust, DM ^{[1
]}

机构：

[1] Inst Pasteur, Dept Biol Mol, CNRS, URA 1773,Unite Genet Differenciat, F-75724 Paris, France

来源：

FEBS LETTERS | 2000年 / 476卷 / 03期

关键词：

cAMP-dependent protein kinase; 5 '-untranslated region; alternative transcript;

D O I：

10.1016/S0014-5793(00)01653-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The activity of cAMP-dependent protein kinase is controlled by its regulatory subunits. Mouse RI alpha regulatory subunit expression is initiated from five different non-coding 5'-regions (exons 1a, 1b. 1c, 1d and 1e). This organization appears to be conserved among species. All mouse tissues accumulate exon 1a and 1b transcripts and most contain more 1b than 1a, except brain, heart and oesophagus. Exon 1d and 1e transcripts are found in several tissues, while exon 1c is testis-specific. All five transcripts are in RI alpha-rich tissues: gonads and adrenal glands. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：272 / 276

页数：5

共 23 条

[1]

ALLEN RW, 1987, J BIOL CHEM, V262, P649

[2] Compensatory regulation of RI alpha protein levels in protein kinase A mutant mice [J].

Amieux, PS ;

Cummings, DE ;

Motamed, K ;

Brandon, EP ;

Wailes, LA ;

Le, K ;

Idzerda, RL ;

McKnight, GS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (07) :3993-3998

[3]

AUSUBEL IM, 1999, CURRENT PROTOCOLS MO

[4] DISTINCT PATTERNS OF CAMP-DEPENDENT PROTEIN-KINASE GENE-EXPRESSION IN MOUSE-BRAIN [J].

CADD, G ;

MCKNIGHT, GS .

NEURON, 1989, 3 (01) :71-79

[5] Gamma-glutamyl transpeptidase gene organization and expression: a comparative analysis in rat, mouse, pig and human species [J].

Chikhi, N ;

Holic, N ;

Guellaen, G ;

Laperche, Y .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 1999, 122 (04) :367-380

[6] ISOLATION OF BIOLOGICALLY-ACTIVE RIBONUCLEIC-ACID FROM SOURCES ENRICHED IN RIBONUCLEASE [J].

CHIRGWIN, JM ;

PRZYBYLA, AE ;

MACDONALD, RJ ;

RUTTER, WJ .

BIOCHEMISTRY, 1979, 18 (24) :5294-5299

[7] THE GENETIC SUBTYPES OF CAMP-DEPENDENT PROTEIN-KINASE - FUNCTIONALLY DIFFERENT OR REDUNDANT [J].

DOSKELAND, SO ;

MARONDE, E ;

GJERTSEN, BT .

BIOCHIMICA ET BIOPHYSICA ACTA, 1993, 1178 (03) :249-258

[8]

FAUST DM, 1994, CELL GROWTH DIFFER, V5, P47

[9] CYCLIC-AMP STIMULATES SOMATOSTATIN GENE-TRANSCRIPTION BY PHOSPHORYLATION OF CREB AT SERINE-133 [J].

GONZALEZ, GA ;

MONTMINY, MR .

CELL, 1989, 59 (04) :675-680

[10] Accumulation in fetal muscle and localization to the neuromuscular junction of cAMP-dependent protein kinase A regulatory and catalytic subunits RI alpha and C alpha [J].

ImaizumiScherrer, T ;

Faust, DM ;

Benichou, JC ;

Hellio, R ;

Weiss, MC .

JOURNAL OF CELL BIOLOGY, 1996, 134 (05) :1241-1254

← 1 2 3 →